Charlie Nancy leads a normal, boring existence in London. However, when he calls the U.S. to invite his estranged father to his wedding, he learns that the man just died. After jetting off to Florida for the funeral, Charlie not only discovers a brother he didn't know he had, but also learns that his father was the West African trickster god, Anansi. Charlie's brother, who possesses his own magical powers, later visits him at home and spins Charlie's life out of control, getting him fired, sleeping with his fiancée, and even getting him arrested for a white-collar crime. Charlie fights back with assistance from other gods, and that's when the real trouble begins. They lead the brothers into adventures that are at times scary or downright hysterical. At first Charlie is overwhelmed by this new world, but he is Anansi's son and shows just as much flair for trickery as his brother.